WebDec 12, 2024 · IGF2BP2 controls glutamine metabolism in AML by targeting GPT2, ... we have developed an effective small-molecule inhibitor (namely CWI1-2) that preferentially binds to IGF2BP2 and inhibits its interaction with m 6 A-modified target transcripts. Targeting IGF2BP2 with CWI1-2 alone, or in combination with other agents such as daunorubicin … WebThe glutamate pyruvate transaminases GPT (or GPT1) and GPT2, also designated alanine aminotransferases (ALT1 and ALT2), respectively, catalyze the reversible transamination …
GFPT2 Gene - GeneCards GFPT2 Protein GFPT2 Antibody
WebFeb 14, 2024 · Glutamine starvation or GLS inhibition induces expression of GPT2. a Relative mRNA levels of GLS1, GLUD1, GOT2, and GPT2 in … WebAug 1, 2024 · This proposal is based on our preliminary studies showing that: (i) CRCs with PIK3CA mutations are addicted to glutamine through upregulation of glutamate pyruvate transaminase 2 (GPT2); (ii) a glutaminase inhibitor, CB-839, suppresses the growth of PIK3CA mutant CRC xenografts; (iii) aminooxyacetate (AOA), an inhibitor of GPT2 and … red peppers powder
High throughput screen for GPT2 inhibitors to target PIK3CA
WebApr 15, 2024 · A fine balance between cancer metabolism and autophagy is a prerequisite of homeostasis within cancer cells. Here we show that glutamate pyruvate transaminase 2 (GPT2), which serves as a pivot between glycolysis and glutaminolysis, is highly upregulated in aggressive breast cancers, particularly the triple-negative breast cancer … Web(BPTES), an inhibitor of GLS [9], we found that GPT2 was highly induced (Fig. 1d, e and Supplementary Fig. 1C). We also observed a similar induction of GPT2 with another WebThe results suggested that V-9302 (SLC1A5 inhibitor) and AOA (GPT2 inhibitor) could significantly suppress SRCC organoids proliferation ( Figure 4A,B). In contrast, V-9302 and AOA had no effect... red peppers phytochemicals