Thp1 sting
WebConsistently, STING agonist payload treatment in the presence of conditioned media from PBMC and primary monocyte but not from THP1 cultures, led to STING activation in … WebFigure 1 IFN-γ and LPS cooperatively induce CCL2 in monocytic cells/macrophages. THP-1 monocytic cells, primary monocytes, and THP-1-derived macrophages were treated for 24h with IFN-γ (10 ng/mL) alone or in combination with LPS (10 ng/mL). Total RNA was extracted and Ccl2 mRNA expression was quantified by real-time RT-PCR.
Thp1 sting
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[email protected] Toll-Free: (855)Go-Glixx Tel: 781-333-5348 Fax: 781-333-5368 . STING agonist D61. CAS: N/A. Chemical Name: 2-(1-Ehyl-3-methyl-1H-pyrazole-5-carboxamido)-7-meth WebSR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic …
WebSep 10, 2024 · In these cell lines STING was expressed under the viral hEF1-HTLV promoter and so levels of STING were significantly higher than in cell lines such as THP1. Using … WebThe innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of …
WebStimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision of diagnostic or therapeutic outcomes. In this study, we report the design, WebIn order to study which pathway that the RNA-DNA complex activates the immune response, the researchers generatedMAVS, cGAS,STING knockout THP-1 cell lines, and introduced …
WebSTING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., …
WebApr 15, 2024 · CODETHP-1 (human)THP1-Blue™ KI-IP10Lucia knocked into human IP10 (CXCL10) (parental cell line THP1-Blue™ NF-κB) / thpb-ip10kilc ※ INFLAMMASOME test and reporter cellsInflammasome test & reporter cells : Colorimetric (620-655 nm) / : Luminescent / : Fluorescence (GFP)CELL LINEPRODUCTPATHWAYS STUDIED / … otterbox aura edge reviewWebThe role of cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway in cancer immunity has been increasingly recognized in recent years (3, … otterbox asus zenfoneWebJan 22, 2011 · The endogenous STING agonist is 2'3'-cGAMP, ... that has similar affinity for hSTING in vitro and is ten times more potent at inducing IFN-β secretion from human … otterbox at\u0026tWebJun 20, 2024 · THP1-Dual and THP1-Dual KO-STING cells were maintained in RPMI containing 10% FCS, 1% penicillin/streptomycin, 0.2% normicin, 200 μg/mL Zeocin and 20 … otterbox attachmentsWebNational Center for Biotechnology Information otterbox australia iphone 13WebDec 12, 2024 · We then analyzed whether infection of THP1 cells by different viruses could alter the expression of wt STING and the E7-less hSTING isoforms. Because some viruses … otterbox at\\u0026tWebSR-717 free acid is a non-nucleotide STING agonist with EC 50 s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity. otterbox at walmart